n/a
Abstract Title:

Curcumin: An Insight to Molecular Pathways Involved in Anticancer Activity.

Abstract Source:

Mini Rev Med Chem. 2021 Jan 22. Epub 2021 Jan 22. PMID: 33480345

Abstract Author(s):

Priyanka Joshi, Sushil Joshi, Deepak Semwal, Akansha Bisht, Sarvesh Paliwal, Jaya Dwivedi, Swapnil Sharma

Article Affiliation:

Priyanka Joshi

Abstract:

Curcuma longa has been mentioned in Indian system of medicine for the management of wide range of diseases. C. longa and its metabolites like curcumin, ar-turmerone, methyl-curcumin, demethoxy-curcumin, bisdemethoxy-curcumin have also been reported beneficial in various types of cancer. Curcumin elicits anticancer properties chiefly by triggering apoptotic pathways in cancer cells. The properties are facilitated through diverse signaling pathways viz. pathways mediated by NF-kB, WNT/β-catenin pathway COX-2, LOX, STAT3, prostaglandin E2, phosphorylase kinase, VEGF, AKT, AP1, STAT3, PI3K, Akt, mTOR, ERK5, AP-1, TGF-b, PPARc, EBPa, NLRP3 inflammasome, p38MAPK, Nrf2, Notch-1, AMPK, TLR-4 etc. Present article highlights curcumin biosynthesis, phytochemistry and diverse molecular pathways involved to regulate several types of secondary messengers to exhibit anticancer activity in almost all the forms of cancer.

Print Options


Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.