Article Publish Status: FREE
Abstract Title:

Curcumin therapy in a Plp1 transgenic mouse model of Pelizaeus-Merzbacher disease.

Abstract Source:

Ann Clin Transl Neurol. 2015 Aug ;2(8):787-96. Epub 2015 Jun 24. PMID: 26339673

Abstract Author(s):

Dirk B Epplen, Thomas Prukop, Tobias Nientiedt, Philipp Albrecht, Friederike A Arlt, Ruth M Stassart, Celia M Kassmann, Axel Methner, Klaus-Armin Nave, Hauke B Werner, Michael W Sereda

Article Affiliation:

Dirk B Epplen


OBJECTIVE: Pelizaeus-Merzbacher disease (PMD) is a progressive and lethal leukodystrophy caused by mutations affecting the proteolipid protein (PLP1) gene. The most common cause of PMD is a duplication of PLP1 and at present there is no curative therapy available.

METHODS: By using transgenic mice carrying additional copies of Plp1, we investigated whether curcumin diet ameliorates PMD symptoms. The diet of Plp1 transgenic mice was supplemented with curcumin for 10 consecutive weeks followed by phenotypical, histological and immunohistochemical analyses of the central nervous system. Plp1 transgenic and wild-type mice fed with normal chow served as controls.

RESULTS: Curcumin improved the motor phenotype performance of Plp1 transgenic mice by 50% toward wild-type level and preserved myelinated axons by 35% when compared to Plp1 transgenic controls. Furthermore, curcumin reduced astrocytosis, microgliosis and lymphocyte infiltration in Plp1 transgenic mice. Curcumin diet did not affect the pathologically increased Plp1 mRNA abundance. However, high glutathione levels indicating an oxidative misbalance in the white matter of Plp1 transgenic mice were restored by curcumin treatment.

INTERPRETATION: Curcumin may potentially serve as an antioxidant therapy of PMD caused by PLP1 gene duplication.

Study Type : Transgenic Animal Study

Print Options

Key Research Topics

Sayer Ji
Founder of

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022, Journal Articles copyright of original owners, MeSH copyright NLM.