Abstract Title:

Interaction between curcumin and opioid system in the formalin test of rats.

Abstract Source:

Pak J Biol Sci. 2007 Aug 1;10(15):2583-6. PMID: 19070135

Abstract Author(s):

Hossein Tajik, Esmaeal Tamaddonfard, Nasrin Hamzeh-Gooshchi

Article Affiliation:

Department of Food Hygiene, College of Veterinary Medicine, Urmia University, Urmia, Iran.


In this study, the effect of curcumin on the formalin-induced pain was investigated in rats. Interaction between curcumin and opioid system using morphine and naloxone was also examined. A biphasic pain response was induced after intraplantar injection of formalin (50 microL, 1%). Curcumin, morphin and naloxone had no effect on the early phase of pain. Late phase of pain was suppressed by curcumin at the doses of 100 and 200 mg kg(-1) body weigh. Morphine (1 mg kg(-1) BW) reduced, whereas naloxone (1 mg kg(-1) BW) did not affect the late phase of pain. Currcumin did not influence the morphine-induced antinociception, but reversed the effect of naloxone on pain. Present findings indicate that curcumin may produce antinociception by activation of both opioid and non opioid mechanisms of pain.

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Sayer Ji
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