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Abstract Title:

Curcumin: reclaiming the lost ground against cancer resistance.

Abstract Source:

Cancer Drug Resist. 2021 ;4(2):298-320. Epub 2021 Jun 19. PMID: 35582033

Abstract Author(s):

Siraj Shaikh, Javed Shaikh, Yusufi Sadia Naba, Kailas Doke, Khursheed Ahmed, Mujahid Yusufi

Article Affiliation:

Siraj Shaikh

Abstract:

Curcumin, a polyphenol, has a wide range of biological properties such as anticancer, antibacterial, antitubercular, cardioprotective and neuroprotective. Moreover, the anti-proliferative activities of Curcumin have been widely studied against several types of cancers due to its ability to target multiple pathways in cancer. Although Curcumin exhibited potent anticancer activity, its clinical use is limited due to its poor water solubility and faster metabolism. Hence, there is an immense interest among researchers to develop potent, water-soluble, and metabolically stable Curcumin analogs for cancer treatment. While drug resistance remains a major problem in cancer therapy that renders current chemotherapy ineffective, curcumin has shown promise to overcome the resistance and re-sensitize cancer to chemotherapeutic drugs in many studies. In the present review, we are summarizing the role of curcumin in controlling the proliferation of drug-resistant cancers and development of curcumin-based therapeutic applications from cell culture studies up to clinical trials.

Study Type : Review

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Sayer Ji
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