Article Publish Status: FREE
Abstract Title:

Effect of curcumin supplementation on physiological fatigue and physical performance in mice.

Abstract Source:

Nutrients. 2015 ;7(2):905-21. Epub 2015 Jan 30. PMID: 25647661

Abstract Author(s):

Wen-Ching Huang, Wan-Chun Chiu, Hsiao-Li Chuang, Deh-Wei Tang, Zon-Min Lee, Li Wei, Fu-An Chen, Chi-Chang Huang

Article Affiliation:

Wen-Ching Huang


Curcumin (CCM) is a well-known phytocompound and food component found in the spice turmeric and has multifunctional bioactivities. However, few studies have examined its effects on exercise performance and physical fatigue. We aimed to evaluate the potential beneficial effects of CCM supplementation on fatigue and ergogenic function following physical challenge in mice. Male ICR mice were divided into four groups to receive vehicle or CCM (180μg/mL) by oral gavage at 0, 12.3, 24.6, or 61.5 mL/kg/day for four weeks. Exercise performance and anti-fatigue function were evaluated after physical challenge by forelimb grip strength, exhaustive swimming time, and levels of physical fatigue-associated biomarkers serum lactate, ammonia, blood urea nitrogen (BUN), and glucose and tissue damage markers such as aspartate transaminase (AST), alanine transaminase (ALT), and creatine kinase (CK). CCM supplementation dose-dependently increased grip strength and endurance performance and significantly decreased lactate, ammonia, BUN, AST, ALT, andCK levels after physical challenge. Muscular glycogen content, an important energy source for exercise, was significantly increased. CCM supplementation had few subchronic toxic effects. CCM supplementation may have a wide spectrum of bioactivities for promoting health, improving exercise performance and preventing fatigue.

Study Type : Animal Study

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