Abstract Title:

Neuroprotective effect of curcumin is mainly mediated by blockade of microglial cell activation.

Abstract Source:

Pharmazie. 2007 Dec;62(12):937-42. PMID: 18214347

Abstract Author(s):

Hae Sung Lee, Ki Kyung Jung, Jae Youl Cho, Man Hee Rhee, Sungyoul Hong, Moosik Kwon, Seung Hee Kim, Seog Youn Kang


Curcumin, the major yellow pigment in turmeric (Curcuma longa), is a well-documented naturally-occurring anti-oxidant with numerous pharmacological activities such as anti-inflammatory, anti-carcinogenic and anti-bacterial effects. In this study, curcumin's neuroprotective effect was carefully examined using a coculture system, based on reports that curcumin-containing plants are neuroprotective. Coculturing neuronal cells and activated microglial cells enhanced dopamine-induced neuronal cell death from 30% up to 50%. However, curcumin did not protect dopamine-directed neuronal cell death and sodium nitroprosside (SNP)-induced NO generation, but only blocked activated microglial cell-mediated neuronal cell damage under inflammatory conditions. Indeed, curcumin blocked the production of pro-inflammatory and cytotoxic mediators such as NO, TNF-alpha, IL-1alpha, and IL-6 produced from Abeta(25-35)/IFN-gamma- and LPS-stimulated microglia, in a dose-dependent manner. Therefore, our results suggest that curcumin-mediated neuroprotective effects may be mostly due to its anti-inflammatory effects.

Study Type : In Vitro Study

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Sayer Ji
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