Article Publish Status: FREE
Abstract Title:

Curcumol Undermines SDF-1/CXCR4/NF-B Signaling Pathway to Suppress the Progression of Chronic Atrophic Gastritis (CAG) and Gastric Cancer.

Abstract Source:

Evid Based Complement Alternat Med. 2022 ;2022:3219001. Epub 2022 Sep 16. PMID: 36159583

Abstract Author(s):

Xuehui Ma, Lingjing Kong, Wen Zhu, Yongli Wang, Zhengbo Zhang, Yaozhou Tian

Article Affiliation:

Xuehui Ma


CAG is the most common precancerous disease of gastric cancer, which belongs to a kind of chronic gastritis. CAG is in close association with gastric cancer, which makes itself a critical node clinically in cancer prevention and treatment. Curcumol is a main active monomer in Fuzheng Huowei decoction, which has the properties of antioxidant, antiviral, and antitumor. In this study, the expression of SDF-1/CXCR4/NF-B was detected by in vivo and in vitro methods. Then, we found that the expressions of NF-B, SDF-1, CXCR4, and p-NF-B were decreased in the curcumol treatment group. Curcumol inhibited gastric cancer cells' viability, migration, and invasion and induced their apoptosis. After adding the lentivirus overexpressing SDF-1to the curcumol treatment group, it was found that SDF-1, CXCR4, NF-B, and p-NF-B protein expressions were all increased, and the effect of curcumol on gastric cancer cells was reversed. In the nude mouse experiment, the tumor volume in the curcumol + SDF-1group was the largest, and the tumor volume in the Fuzheng Huowei decoction + NC group was the smallest. In conclusion, curcumol effectively protects gastric tissue and inhibits the viability of gastric cancer cells, and curcumol regulates SDF-1/CXCR4/NF-B to play a therapeutic role in chronic atrophic gastritis and gastric cancer.

Study Type : In Vitro Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2023 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.