Abstract Title:

Anti-aging effects of cyanidin under a stress-induced premature senescence cellular system.

Abstract Source:

Biol Pharm Bull. 2010;33(3):421-6. PMID: 20190403

Abstract Author(s):

Mi Jin Choi, Boh Kyung Kim, Kun Young Park, Takako Yokozawa, Young Ok Song, Eun Ju Cho

Article Affiliation:

Department of Food Science and Nutrition, Research Institute of Ecology for the Elderly, Pusan National University, Jangjeon-dong, Geumjeong-gu, Busan 609-735, Korea.


The anti-aging effects of cyanidin were investigated under stress-induced premature senescence (SIPS) using WI-38 human diploid fibroblasts. WI-38 cells that were treated with 300 microM H(2)O(2) showed losses of cell viability, increased lipid peroxidation, and shortened cell lifespans. However, treatment with cyanidin attenuated cellular oxidative stress through increase of cell viability and the inhibition of lipid peroxidation. In addition, the life spans of young-, middle-, and old-aged WI-38 cells were prolonged by cyanidin treatment. Furthermore, H(2)O(2)-treated WI-38 cells significantly increased mRNA and protein expressions of nuclear factor-kappaB, cyclooxygenase-2, and inducible nitric oxide synthase, while those treated with cyanidin had significantly decreased expressions. These results suggest that cyanidin may delay the aging process by attenuating oxidative stress under the SIPS cellular model.

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & receive The Dark Side of Wheat Ebook

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

The Dark Side of Wheat

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2023 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.