Article Publish Status: FREE
Abstract Title:

Cyclophosphamide-induced testicular toxicity ameliorate bytreatment: An experimental study.

Abstract Source:

Int J Reprod Biomed (Yazd). 2018 Nov ;16(11):711-718. PMID: 30775687

Abstract Author(s):

Akram Hosseini, Samad Zare, Zahra Borzouei, Firouz Ghaderi Pakdel

Article Affiliation:

Akram Hosseini


Background: Cyclophosphamide (CP) is one of the most invasive chemotherapeutic agents, which used commonly despite of its wide spectrum toxicity. Clinical evidence showed toxic side effects of CP in multiple organ systems.

Objective: The objective of the present study was to evaluate the effects ofon CP-induced testicular toxicity in rats.

Materials and Methods: Adult male Wistar rats (220±30 gr) were randomly divided into four groups (n=7 in each). Group 1 as control received normal saline by gavage, group 2 received CP (6.1 mg/kg/day, i.p.) for a period of 50 days. Group 3 received(500 mg/kg/day) by gavage. Group 4 received(500 mg/kg/day) 1h prior to the administration of CP in the equal dose of group 2. The animals scarified one day after the last treatment and the effects ofon the sperm vital parameters, testicular functions, biochemical factors, and structural malformations evaluated.

Results: Serum testosterone concentration was significantly decreased whereas the level of malondialdehyde and DNA damage were significantly increased in animals of CP group (p<0.01). Co-administration ofreversed these parameters and improved recovery in CP+ginseng group. In addition, seminiferous tubules of testis severely damaged in the CP group but ginseng improved histologic changes in CP+ginseng group.

Conclusion: The findings confirmed the protective effects ofon toxicity induced by CP in the reproductive system of male rats.

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