Abstract Title:

Cytotoxic and antibacterial triterpenoids from the roots of Morinda officinalis var. officinalis.

Abstract Source:

Fitoterapia. 2019 Mar ;133:56-61. Epub 2018 Dec 21. PMID: 30579769

Abstract Author(s):

Hui-Juan Zhai, Jin-Hai Yu, Qianqian Zhang, Hai-Shan Liu, Jun-Sheng Zhang, Xiu-Qing Song, Yuying Zhang, Hua Zhang

Article Affiliation:

Hui-Juan Zhai


Seven new pentacyclic triterpenoids including six ursane-type, marinoids A-F (1-6), and one oleanane-type, marinoid G (7), along with five known analogues (8-12), were separated from the roots of Morinda officinalis var. officinalis. Their structures were assigned by spectroscopic means especially analysis of 2D NMR data, with the absolute configurations of 1 and 2 being determined via comparison of their experimental ECD spectra with the computed ones. Selective compounds displayed cytotoxic activity against two human osteosarcoma cell lines and also antibacterial effects against one Gram positive and one Gram negative strains.

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