Abstract Title:

β-d-glucan from Antrodia Camphorata ameliorates LPS-induced inflammation and ROS production in human hepatocytes.

Abstract Source:

Int J Biol Macromol. 2017 Nov ;104(Pt A):768-777. Epub 2017 Jun 19. PMID: 28642114

Abstract Author(s):

Qiuli Chen, Huiling Tang, Zhengqi Zha, Hongping Yin, Ying Wang, Yufeng Wang, Haitao Li, Long Yue

Article Affiliation:

Qiuli Chen


A water soluble Antrodia Camphorata polysaccharide was composed ofβ-d-glucan, coded as ACP1. ACP1 was derived from cultured Antrodia Camphorata powder, which was extracted, separated and purified by DEAE-52 column and Sephadex G-100 chromatography. The molecular weight of ACP1 was 1.72×10Da, and ACP1 consisted of glucose and galactose in the mole ratio of 2.21:1. Structural identification by FTIR, GC-MS and NMR, inferred that ACP1 consisted of→1,3)-linked-β-d-Glcp-(6→, →3)-linked-β-d-Glcp-(1→, and →6)-linked-α-d-Galp-(1→, with terminal β-d-Glcp and β-d-Galp. The anti-inflammation and anti-oxidation effects of ACP1 were examined in LPS-treated L02 cells in this study. The results demonstrated that ACP1 not only attenuatedROS production, but also decreased expressions of TNF-α and IL-1β. Furthermore, ACP1 reduced the proteins expression of NOX1, NOX2 and NOX4, as well as phosphorylation of ERK, p38 and Akt. The results suggested ACP1 was very likely to alleviate oxidation and inflammation via the suppression of NADPH oxidase activation and inhibition of ERK, p38 and Akt signaling pathways.

Print Options

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.