Abstract Title:

D-ribose aids advanced ischemic heart failure patients.

Abstract Source:

Int J Cardiol. 2008 Jul 30. [Epub ahead of print] PMID: 18674831

Abstract Author(s):

Dean MacCarter, Nampalli Vijay, Melinda Washam, Linda Shecterle, Helen Sierminski, J A St Cyr

Abstract:

Full Citation: "Patients with advanced heart failure are exercise intolerant. Low cellular energy levels in the failing heart have been proposed. Energy enhancing substrates have revealed mixed results. Ribose, a pentose monosaccharide, has shown to replenish low myocardial energy levels, improving cardiac dysfunction following ischemia, and improving ventilation efficiency in patients with heart failure. As current pharmaceuticals do not address cellular energy levels, this study was designed to investigate the role of ribose on ventilation at anaerobic threshold in congestive heart failure patients. d-ribose (5gms/dose, tid) was assessed in 16 NYHA class III-IV, heart failure patients with VO(2), tidal volume/VCO(2), heart rate/tidal volume evaluated at 8 weeks. All patients had a significant improvement in ventilatory parameters at anaerobic threshold, along with a 44% Weber class improvement. Ribose improved the ventilatory exercise status in advanced heart failure patients."

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