Abstract Title:

Enhancing the natural killer cell activity and anti-influenza effect of heat-treated Lactobacillus plantarum nF1-fortified yogurt in mice.

Abstract Source:

J Dairy Sci. 2018 Oct 10. Epub 2018 Oct 10. PMID: 30316596

Abstract Author(s):

Da Hyun Kim, Woo-Chang Chung, Su-Hyun Chun, Ji Ho Han, Moon Jung Song, Kwang-Won Lee

Article Affiliation:

Da Hyun Kim


Influenza A virus (IAV) infection is a global public health concern. It causes respiratory diseases ranging from mild illness to fatal disease. Natural killer (NK) cells are an innate immune component that kill infected cells and secrete cytokines to modulate the adaptive immune system; they constitute the first-line defense and play important roles in controlling IAV infection. This study evaluated the effect of daily administration of heat-treated Lactobacillus plantarum nF1-fortified yogurt on immunity and protection against IAV infection. Mice administered with heat-treated L. plantarum nF1-fortified yogurt showed elevated NK cell-related cytokine expression levels. Daily administration of the L. plantarum nF1-fortified yogurt before IAV infection also enhanced splenic NK activity, lung inflammatory cytokine responses, and survival rate. Thus, daily administration of nF1-fortified yogurt enhances host immunity and helps prevent IAV infection.

Study Type : Animal Study

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Sayer Ji
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