Abstract Title:

Daily ingestion of green tea catechins from adulthood suppressed brain dysfunction in aged mice.

Abstract Source:

Biofactors. 2008;34(4):263-71. PMID: 19850981

Abstract Author(s):

Keiko Unno, Yuichi Ishikawa, Fumiyo Takabayashi, Toru Sasaki, Nina Takamori, Kazuaki Iguchi, Minoru Hoshino

Article Affiliation:

Laboratory of Bioorganic Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, Suruga-ku, Shizuoka, Japan. [email protected]


Oxidative damage is believed to be an important cause of senescence. We have previously found that green tea catechins (GT-catechin), potent antioxidants, decrease oxidative damage to DNA and suppress brain dysfunction in aged senescence-accelerated mice (SAMP10) when ingested from the age of 1 month to the age of 12 months. To clarify the effect of GT-catechin on suppression of brain senescence, we investigated the effect of starting period to ingest GT-catechin. Six- or 9-month-old SAMP10 mice were allowed free access to water containing 0.02% GT-catechin. SAMP10 mice exhibit senescence characteristics such as shortened life span, atrophied forebrain and lowered learning and memory abilities. Learning ability was significantly higher in mice that ingested GT-catechin from the age of 6 months to 12 months when compared with same-aged control mice drank water without GT-catechin. Starting GT-catechin intake from the age of 9 months tended to improve learning ability. The ages of 6 and 9 months are thought to be adult and middle ages, respectively in SAMP10 mice. This result suggested that GT-catechin was helpful in suppressing brain dysfunction with aging even when ingestion started at the adult age.

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Sayer Ji
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