Abstract Title:

Orally administered mixed carotenoids protect human skin against Ultraviolet A-induced skin pigmentation: A double blind, placebo controlled, randomized clinical trial.

Abstract Source:

Photodermatol Photoimmunol Photomed. 2020 Feb 18. Epub 2020 Feb 18. PMID: 32072695

Abstract Author(s):

Sudhir M Baswan, Alessandra Marini, Allison E Klosner, Thomas Jaenicke, Jesse Leverett, Mary Murray, Kevin W Gellenbeck, Jean Krutmann

Article Affiliation:

Sudhir M Baswan


BACKGROUND: Photoprotection of human skin is determined as the capacity of sunscreens to prevent Ultraviolet (UV) B radiation-induced erythema and UVA radiation-induced pigmentation. It is unequivocal that, in addition to sunscreens, oral supplementation with carotenoids can protect human skin against UVB radiation-induced erythema. It is not known if this is also the case for UVA radiation-induced pigmentation.

OBJECTIVE: To clinically evaluate the photoprotective effects of daily supplementation with carotenoids against UVA radiation-induced pigmentation.

METHODS: In this double blind, placebo-controlled trial, 60 subjects (Fitzpatrick types II-IV) were randomized to receive Nutrilite™ Multi Carotene supplement or placebo for 12-weeks. UVB-induced Minimal Erythemal dose (MED), UVA-induced Minimal Persistent Pigmentation Dose (MPPD) and skin carotenoid levels were measured at baseline, 4, 8 and 12 weeks of intervention. Skin color was evaluated by expert clinical graders and bycolorimetry . Carotenoid levels in the skin were measured by the Biozoom® device.

RESULTS: In the intervention group, a significant increase in comparison with the placebo group was observed in (i) skin carotenoid levels, (ii) UVB-induced MED and (iii) UVA-induced MPPD values obtained by colorimetry.

CONCLUSION: Daily supplementation with carotenoids protects human skin against both UVB-induced erythema and UVA-induced pigmentation.

Study Type : Human Study

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