Article Publish Status: FREE
Abstract Title:

Vitamin D and Delirium in Older Adults: A Case-Control Study in Geriatric Acute Care Unit.

Abstract Source:

Front Neurol. 2020 ;11:1034. Epub 2020 Sep 18. PMID: 33071932

Abstract Author(s):

Justine Chouët, Guillaume Sacco, Spyridon N Karras, David J Llewellyn, Dolores Sánchez-Rodríguez, Cédric Annweiler

Article Affiliation:

Justine Chouët


Vitamin D is involved in brain health and function. Our objective was to determine whether the serum 25-hydroxyvitamin D (25OHD) concentration was associated with delirium in a case-control study of geriatric inpatients.Sixty cases with delirium (mean± SD, 84.8 ± 5.7years; 58.3% female) and 180 age- and gender-matched controls were enrolled in a geriatric acute care unit between 2012 and 2014. The diagnosis of delirium was made using the Confusion Assessment Method. Hypovitaminosis D was defined using consecutively the consensual threshold value of 50 nmol/L and a threshold value calculated from a sensitivity-specificity analysis. Age, gender, number of acute diseases, use of psychoactive drugs, season of testing, and serum concentrations of calcium, parathyroid hormone, creatinine, albumin, TSH, vitamin B9 and vitamin B12 were used as potential confounders.The 60 cases with delirium exhibited lower 25OHD concentration than 180 matched controls (35.4± 30.0 nmol/L vs. 45.9 ± 34.5 nmol/L,= 0.035). Increased 25OHD concentration was associated with a decrease in delirium prevalence (OR = 0.99 [95CI: 0.98-0.99] per nmol/L of 25OHD,= 0.038). The concentration distinguishing between cases and controls with the best sensitivity-specificity was found between 29.5 and 30.5 nmol/L. The regression models showed that delirium was associated with hypovitaminosis D defined either as 25OHD≤ 50 nmol/L (OR = 2.37 [95CI: 1.07-5.25],= 0.034) or as 25OHD≤ 30 nmol/L (OR = 2.66 [95 CI: 1.30-5.45],= 0.008).Decreased serum 25OHD concentrations were associated with delirium among acute geriatric inpatients. The threshold concentration to differentiate between cases and controls was around 30 nmol/L.

Study Type : Human Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2022 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.