Abstract Title:

Delayed focal lipoatrophy after AS03-adjuvanted influenza A (H1N1) 2009 vaccine.

Abstract Source:

Vaccine. 2010 Dec 17. Epub 2010 Dec 17. PMID: 21172376

Abstract Author(s):

Emilie Javelle, Benjamin Soulier, Christian Brosset, Solène Lorcy, Fabrice Simon

Article Affiliation:

Department of Infectious Diseases and Tropical Medicine, Laveran Military Teaching Hospital, 4, Boulevard Laveran, BP 60149, 13 384 Marseille Cedex 13, France.

Abstract:

Intramuscular vaccination may lead to loss of subcutaneous fat resulting in skin depression at the site of injection. We report for the first time a delayed lipoatrophy after with AS03-adjuvanted influenza A (H1N1) 2009 vaccine. Inadequate administration into the adipose tissue may be causative. During next pandemic, education to optimal intramuscular administration and prolonged monitoring of adverse effects could be proposed.

Study Type : Human: Case Report

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