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Abstract Title:

Delphinidin diminishes in vitro interferon-γ and interleukin-17 producing cells in patients with psoriatic disease.

Abstract Source:

Immunol Res. 2021 Nov 25. Epub 2021 Nov 25. PMID: 34825313

Abstract Author(s):

Sotirios G Tsiogkas, Αthanasios Mavropoulos, Dimitrios N Skyvalidas, Eleni Patrikiou, Niki Ntavari, Athina Ioanna Daponte, Maria G Grammatikopoulou, Efthimios Dardiotis, Aggeliki-Victoria Roussaki-Schulze, Lazaros I Sakkas, Efterpi Zafiriou, Dimitrios P Bogdanos

Article Affiliation:

Sotirios G Tsiogkas

Abstract:

The anthocyanidin delphinidin reduces psoriasiform lesions and inflammatory mediators in human cell culture systems. Its role in psoriatic disease has not yet been investigated. We assessed delphinidin's in vitro immunomodulatory effect on ex vivo stimulated peripheral blood mononuclear cells (PBMCs) from 50 individuals [26 with psoriasis, 10 with psoriatic arthritis (PsA) and 14 healthy controls (HCs)]. Cells were either left untreated or stimulated with PMA plus ionomycin in the presence or absence of delphinidin. Intracellular production of interferon-γ (IFNγ), interleukin-17A (IL-17A), and interleukin-10 (IL-10) was measured flow cytometrically. Delphinidin dose-dependently reduced IFNγT cells from patients and HCs. The mean IFNγ decrease in CD4T subpopulations was 42.5 ± 28% for psoriasis patients, 51.8 ± 21.5% for PsA patients and 49 ± 17% for HCs (p < 0.001 for all). Similarly, IFNγ reduction in CD8T cells was 34 ± 21.6% for psoriasis patients, 47.1 ± 22.8% for PsA and 44.8 ± 14.3% for HCs (P< 0.001 for all). An inhibitory effect of delphinidin was also noted in IFNγ producing NKs and NKTs from psoriasis individuals. Delphinidin also significantly decreased IL-17CD4T cells in all tested subjects, with marginal effect on the increase of IL-10-producing T regulatory subsets. In conclusion, delphinidin exerts a profound in vitro anti-inflammatory effect in psoriasis and psoriatic arthritis by inhibiting IFNγinnate and adaptive cells and T helper (Th) 17 cells. If this effect is also exerted in vivo, delphinidin may be regarded as a nutraceutical with immunosuppressive potential.

Study Type : Animal Study, In Vitro Study

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