Abstract Title:

Deltamethrin toxicity: A review of oxidative stress and metabolism.

Abstract Source:

Environ Res. 2018 Dec 21 ;170:260-281. Epub 2018 Dec 21. PMID: 30599291

Abstract Author(s):

Qirong Lu, Yaqi Sun, Irma Ares, Arturo Anadón, Marta Martínez, María-Rosa Martínez-Larrañaga, Zonghui Yuan, Xu Wang, María-Aránzazu Martínez

Article Affiliation:

Qirong Lu


Deltamethrin is widely used worldwide due to its valuable insecticidal activity against pests and parasites. Increasing evidence has shown that deltamethrin causes varying degrees of toxicity. Moreover, oxidative stress and metabolism are highly correlated with toxicity. For the first time, this review systematically summarizes the deltamethrin toxicity mechanism from the perspective of oxidative stress, including deltamethrin-mediated oxidative damage, antioxidant status, oxidative signaling pathways and modulatory effects of antagonists, synergists and placebos on oxidative stress. Further, deltamethrin metabolism, including metabolites, metabolic enzymes and pathways and deltamethrin metabolite toxicity are discussed. This review will shed new light on deltamethrin toxicity mechanisms and provide effective strategies to ensure pest control and prevention of human and animal poisoning.

Study Type : Review

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