Abstract Title:

Resistance exercise reduces memory impairment induced by monosodium glutamate in male and female rats.

Abstract Source:

Exp Physiol. 2017 Apr 23. Epub 2017 Apr 23. PMID: 28436061

Abstract Author(s):

Paulo Cesar Oliveira Araujo, Caroline Brandão Quines, Natália Silva Jardim, Marlon Regis Leite, Cristina Wayne Nogueira

Article Affiliation:

Paulo Cesar Oliveira Araujo


NEW FINDINGS: Monosodium glutamate causes cognitive impairment. Resistance exercise is effective against monosodium glutamate induced memory impairment in male and female mice.

ABSTRACT: Monosodium glutamate (MSG), a flavor enhancer in diets, causes cognitive impairment in humans. Exercise has been reported to protect against impairment of memory in humans. This study investigated if resistance exercise improves the performance of male and female rats treated with MSG in tests of memory and motor coordination. Wistar rats received MSG (4g kg day(-1) , s.c.) from post natal day 1 to 10. At postnatal day 60, the animals started a resistance exercise protocol in an 80° inclined vertical ladder apparatus and performed it during 7 weeks. Rats performed object recognition and location memory tests. Resistance exercise reduced impairment in motor coordination of male and female rats treated with MSG. Resistance exercise was effective against the decrease in exploratory preference in the long-term recognition memory (LTM) for novel objects of male rats treated with MSG. In MSG-treated female rats, resistance exercise was effectiveagainst the decrease in exploratory preference in the novel object location test (OLT). The exploratory preference of female rats in the LTM test was similar in all groups. The short-term memory was not altered by MSG or resistance exercise in male and female rats. This study demonstrates that MSGaffected in a different way memory of male and female rats. Resistance exercise was effective against the decrease in recognition for male and in location memory for female rats treated with MSG. This report demonstrates the beneficial effects of resistance exercise against the prejudice of motor condition and impairment of memory induced by MSG in male and female rats. This article is protected by copyright. All rights reserved.

Study Type : Animal Study
Additional Links
Adverse Pharmacological Actions : Neurotoxic : CK(2424) : AC(562)

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