Immunomodulatory Effects ofExtract in the Prevention of Oral Cancer.
Cancer Prev Res (Phila). 2018 Apr ;11(4):185-186. Epub 2018 Mar 20. PMID: 29559516
Chinthalapally V Rao
In recent times, bitter melon extract (BME) has gained significant attention for its anticancer efficacy against various malignancies. In this issue,and colleagues show that BME prevents the development of 4-nitronitroquinoline 1-oxide-induced oral dysplasia and squamous cell carcinoma (SCC) in an immunocompetent mouse model. Importantly, gene ontology and pathway analyses revealed an elevated expression of s100a9, IL23a, IL1β, and PDCD1/PD1 of immune system during oral cancer development, which was significantly suppressed by BME. Overall, this study demonstrates the potential clinical benefits of BME in preventing and delaying the progression of oral dysplasia to SCC..