Development and Anti-microbial Potential of Topical Formulations Containing Cocos nucifera Linn.
Antiinflamm Antiallergy Agents Med Chem. 2013 Jun 4. Epub 2013 Jun 4. PMID: 23746224
Dept.of Pharmaceutical Technology, School of Pharmacy, International Medical University, Bukit Jalil, 57000 KL, Malaysia. firstname.lastname@example.org.
In order to achieve a better treatment for local wounds and bacterial infections, topical formulations containing Cocos nucifera Linn. were developed and evaluated for their physicochemical properties and antimicrobial efficacy against various strains of microorganisms. Semisolid formulations containing 5% w/w of Cocos nucifera Linn. were prepared by employing different dermatological bases and evaluated for physical appearance, pH, rheological properties, FTIR-spectroscopic analysis, thermodynamic stability and stability studies. The antimicrobial activity of each prepared formulation against various strains of microorganisms was determined using disc-diffusion method. The resultant data was expressed as mean± SD and statistical analysis performed using Shapiro-wilk and Pearson's correlation tests. All the prepared formulations were found to be stable and exhibited suitable physicochemical characteristics including pH, viscosity and spreadability which are necessary for an ideal topical preparation along with strong antimicrobial activity. Carbopol gel base was found to be the most suitable dermatological base for Cocos nucifera Linn. in comparsion to other bases. Cocos nucifera Linn. formulations had shown great potential for wounds and local bacterial infections. Moreover, carbopol gel base with its aesthetic appeal was found to be suitable dermatological base for Cocos nucifera Linn. semisolid formulation as it had demonstrated significant physicochemical properties and greater diffusion when assessed using disk- diffusion method.