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Article Publish Status: FREE
Abstract Title:

Development of Geraniol-Loaded Liposomal Nanoformulations againstColonization in the Pig Gut.

Abstract Source:

J Agric Food Chem. 2022 Jun 15 ;70(23):7004-7014. Epub 2022 Jun 2. PMID: 35653283

Abstract Author(s):

Sotirios I Ekonomou, Pooja Akshay Thanekar, Dimitrios A Lamprou, Edward Weaver, Olena Doran, Alexandros Ch Stratakos

Article Affiliation:

Sotirios I Ekonomou

Abstract:

is a global health threat, with pig production being one of the main sources of human salmonellosis. The current study investigated the antivirulence properties of geraniol for inhibiting the in vitro colonization of. The minimum inhibitory (MIC) and bactericidal concentrations (MBC) of geraniol againstfollowed by the sub-MIC of geraniol were determined. Results provided clear evidence that geraniol at 1/8 MIC can be used as an effective, non-toxic antivirulence compound to inhibit virulence factors (motility, adhesion, and invasiveness) affecting the colonization ofon IPEC-J2 cells. Additionally, the findings signified that microfluidics is an emerging technology suitable for the preparation of stable liposomes with a small size (<200 nm) and high encapsulation efficiency (EE) of up to 92.53%, which can act as effective carriers of geraniol into the pig gastrointestinal tract (GIT), targeting, preventing colonization, and thus increasing the safety of the food supply chain.

Study Type : Animal Study

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