Abstract Title:

Antimycobacterial polyynes of Devil's Club (Oplopanax horridus), a North American native medicinal plant.

Abstract Source:

J Nat Prod. 1997 Nov;60(11):1210-3. PMID: 9392889

Abstract Author(s):

M Kobaisy, Z Abramowski, L Lermer, G Saxena, R E Hancock, G H Towers, D Doxsee, R W Stokes


Two new (3 and 5), as well as three known (1, 2, and 4), polyynes were isolated from Devil's Club (Oplopanax horridus; Araliaceae), a medicinal plant of North America. The structures were established by 1H and 13C NMR. The absolute configurations of 2 and 5 were determined by application of Mosher's method. All the polyynes exhibited significant anti-Candida, antibacterial, and antimycobacterial activity, with an ability to kill Mycobacterium tuberculosis and isoniazid-resistant Mycobacterium avium at 10 micrograms/disk in a disk diffusion assay.

Study Type : In Vitro Study

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