Dieckol inhibits the effects of particulate matter 10 on sebocytes - GreenMedInfo Summary
Dieckol Inhibits the Effects of Particulate Matter 10 on Sebocytes, Outer Root Sheath Cells, and-Pretreated Mice.
Ann Dermatol. 2022 Jun ;34(3):182-190. Epub 2022 May 20. PMID: 35721332
Mi Hee Kwack
Background: Particulate matter (PM) is an air pollutant that can impair the human skin. Antioxidants have been tested to improve PM-induced skin inflammation.
Objective: In this study, we investigated the effects of dieckol on PM-induced inflammation on cultured human sebocytes, outer root sheath (ORS) cells, and mice pretreated with.
Methods: We cultured and treated the sebocytes and ORS cells with 5µM of dieckol and 100 µg/ml of PM10 for 24 h. The-pretreated mice received 5µM of dieckol and 100 µg/ml of PM10. We measured cell viability using MTT assay. Real-time PCR and measurement of reactive oxygen species (ROS) and sebum production analyzed the effects.
Results: Dieckol inhibited the upregulation of the gene expression of the inflammatory cytokines, matrix metalloproteinase (MMP), aryl hydrocarbon receptor, and nuclear factor kappa-light-chain-enhancer of activated B cells by PM10 in the cultured sebocytes and ORS cells and inhibited an increase in ROS production by PM10 in the cultured sebocytes. In addition, dieckol decreased the inflammatory cytokines, MMP, and sebum production in-pretreated mice.
Conclusion: Dieckol effectively reduced the expression of inflammatory biomarkers and the production of sebum in cultured sebocytes, ORS cells, and-pretreated mice.