Article Publish Status: FREE
Abstract Title:

Osteoprotective effect of cordycepin on estrogen deficiency-induced osteoporosis in vitro and in vivo.

Abstract Source:

Biomed Res Int. 2015 ;2015:423869. Epub 2015 Mar 22. PMID: 25874211

Abstract Author(s):

Da-wei Zhang, Hualiang Deng, Wei Qi, Guang-yue Zhao, Xiao-rui Cao

Article Affiliation:

Da-wei Zhang


The purpose of this study was to verify the effect of cordycepin on ovariectomized osteopenic rats. Fifty Wistar female rats used were divided into 5 groups: (1) sham-operation rats (control), (2) ovariectomized (OVX) rats with osteopenia, and (3) OVX'd rats with osteopenia treated with cordycepin (5 mg, 10 mg, and 20 mg) for 8 weeks. After the rats were treated orally with cordycepin, serum alkaline phosphatase (ALP), tartrate resistant acid phosphatase (TRAP), serum osteocalcin (OC), homocysteine (HCY) , C-terminal crosslinked telopeptides of collagen type I (CTX) level, and oxidative stress were examined, respectively. The femoral neck was used for mechanical compression testing. At the same time, we further investigated the effect of cordycepin in vitro assay. The beneficial effects of cordycepin on improvement of osteoporosis in rats were attributable mainly to decrease ALP activity, TRAP activity, and CTX level. At the same time, cordycepin also increases the OC level in ovariectomized osteopenic rats. The histological examination clearly showed that dietary cordycepin can prevent bone loss caused by estrogen deficiency. These experimental results suggest that complementcordycepin is protective after ovariectomized osteopenic in specific way.

Study Type : Animal Study, In Vitro Study

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