Article Publish Status: FREE
Abstract Title:

Dietary Heat-Killed Lactobacillus brevis SBC8803 Attenuates Chronic Sleep Disorders Induced by Psychophysiological Stress in Mice.

Abstract Source:

J Nutr Sci Vitaminol (Tokyo). 2019 ;65(2):164-170. PMID: 31061285

Abstract Author(s):

Sayaka Higo-Yamamoto, Saori Yamamoto, Koyomi Miyazaki, Yasukazu Nakakita, Hirotaka Kaneda, Yoshihiro Takata, Takeshi Nakamura, Katsutaka Oishi

Article Affiliation:

Sayaka Higo-Yamamoto


We previously reported that dietary heat-killed Lactobacillus brevis SBC8803 affects sleep in mice and humans. The present study examined whether SBC8803 improves psychophysiological stress-induced chronic sleep disorders (CSD) using a mouse model characterized by disrupted circadian rhythms of wheel-running activity and sleep-wake cycles. Mice were fed with a diet supplemented with 0.5% heat-killed SBC8803 for 6 wk and imposed stress-induced CSD for last 2 wk. Dietary SBC8803 suppressed the reduction in wheel-running activity induced by CSD. Electroencephalography (EEG) revealed that SBC8803 significantly restored wakefulness and increased non-rapid eye movement (NREM) sleep during the second half of the active phase during CSD. The CSD-induced reduction in EEG slow wave activity, a marker of NREM sleep intensity, during the beginning of the inactive phase was significantly improved by SBC8803 supplementation. These findings suggest that dietary heat-killed SBC8803 confers beneficial effects on insomnia and circadian sleep disorders induced by psychophysiological stress.

Study Type : Animal Study

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