Dietary immature Citrus unshiu alleviates UVB- induced photoaging. - GreenMedInfo Summary
Dietary immaturealleviates UVB- induced photoaging by suppressing degradation of basement membrane in hairless mice.
Heliyon. 2020 Jun ;6(6):e04218. Epub 2020 Jun 15. PMID: 32577577
Ultraviolet (UV) irradiation induces physiological and morphological skin damage, resulting in skin dryness, wrinkle formation, and loss of elasticity. The basement membrane (BM) has been shown to play crucial roles in binding epidermis to dermis tightly, regulating cell differentiation and proliferation, and signaling protein production. Dietary flavonoids have been revealed to improve the damage caused by UV exposure. Immatureis known to contain high concentrations of flavonoids such as hesperidin and narirutin. In this study, the effects of immaturepowder (ICP) on photoaged skin were demonstrated using UVB irradiated hairless mice. Oral administration of ICP improved loss of skin hydration and increase of transepidermal water loss. The histological analyses of hairless mice dorsal skin revealed that oral administration of ICP improved UVB-induced overgrowth of epidermal cell, suppressed epidermal cell mortality and BM destruction. Therefore, the administration of ICP could improve photoaging by protecting the tissues around BM.