Article Publish Status: FREE
Abstract Title:

Dietary pectic oligosaccharide supplementation improves rat reproductive performance via regulating intestinal volatile fatty acids during middle gestation.

Abstract Source:

Anim Nutr. 2020 Jun ;6(2):210-216. Epub 2020 Jan 23. PMID: 32542202

Abstract Author(s):

Minghui Liu, Xiangbing Mao, Daiwen Chen, Bing Yu, Jun He, Ping Zheng, Jie Yu, Junqiu Luo, Yuheng Luo, Jianping Wang, Quyuan Wang, Huifen Wang

Article Affiliation:

Minghui Liu


As a kind of green additive, pectic oligosaccharide (POS) may regulate some physiological functions of animals, such as gut health, antioxidant capacity, immunity and lipid metabolism. This study aimed to identify whether POS administration can improve maternal reproduction, and to determine the possible metabolism. A total of 48 pregnant Wistar rats randomly allotted into 2 groups, and each group was fed a diet supplemented with 0 or 800 mg/kg of POS. Pectic oligosaccharide administration increased rat born number ( < 0.05), did not affect rat embryo number on d 7 of gestation, but increased rat fetus number on d 14 of gestation ( < 0.05). On d 14 of gestation, POS treatment improvedandpopulations and volatile fatty acid concentrations of cecal digesta ( < 0.05), hormone (progesterone and nitric oxide) and cytokine (interleukin 2) concentrations of serum ( < 0.05), and antioxidant capacity of serum (increased total antioxidant capacity and decreased malondialdehyde) and placenta (increased total superoxide dismutase, decreased malondialdehyde) ( < 0.05) in pregnant rats. These results suggest that POS administration improved rat reproduction via decreasing fetus loss in middle gestation. This was due to the increased volatile fatty acid concentrations in rat gut improving hormone and inflammatory-cytokine productions, and antioxidant capacity.

Study Type : Animal Study

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