n/a
Abstract Title:

Pharmacokinetic and Metabolic Profiling of Key Active Components of Dietary SupplementExtract for Prevention against Oral Carcinoma.

Abstract Source:

J Agric Food Chem. 2020 Jun 17 ;68(24):6576-6587. Epub 2020 Jun 4. PMID: 32348135

Abstract Author(s):

Dinh Bui, Li Li, Taijun Yin, Xinli Wang, Song Gao, Ming You, Rashim Singh, Ming Hu

Article Affiliation:

Dinh Bui

Abstract:

Among the three key active components (KACs) ofbark extract (ME), 4--methylhonokiol and honokiol showed higher antiproliferation activities than magnolol in the oral squamous cancer cell lines (Cal-27, SCC-9, and SCC-4). Oral bioavailabilities of ME-KACs were poor (<0.2%) in C57BL/6 mice primarily due to their extensive first-pass phase II metabolism and poor solubilities. High plasma concentration of glucuronides upon oral administration and faster rate of glucuronidation by intestinal microsomes indicated intestine as one of the major metabolic organs for ME-KACs. Despite the increase in bioavailabilities of ME-KACs (∼8-10-fold) and decrease in AUCof glucuronides (∼10-fold) upon ME solubility enhancement, systemic exposure of ME-KACs failed to improve meaningfully. In conclusion, we propose a quality-controlled and chemically defined ME mixture, containing an optimized ratio of three KACs, delivered locally in the oral cavity as the most promising strategyfor ME use as an oral cancer chemopreventive dietary supplement.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Chemopreventive : CK(4220) : AC(1326)

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2020 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.