Abstract Title:

Dietary Whey Protein Decreases Food Intake and Body Fat in Rats.

Abstract Source:

Obesity (Silver Spring). 2011 Feb 17. Epub 2011 Feb 17. PMID: 21331067

Abstract Author(s):

June Zhou, Michael J Keenan, Jack N Losso, Anne M Raggio, Li Shen, Kathleen L McCutcheon, Richard T Tulley, Marc R Blackman, Roy J Martin

Article Affiliation:

1] Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA [2] Louisiana State University Agricultural Center, Baton Rouge, Louisiana, USA [3] Research Service, Veterans Affairs Medical Center, Washington, DC, USA.


We investigated the effects of dietary whey protein on food intake, body fat, and body weight gain in rats. Adult (11-12 week) male Sprague-Dawley rats were divided into three dietary treatment groups for a 10-week study: control. Whey protein (HP-W), or high-protein content control (HP-S). Albumin was used as the basic protein source for all three diets. HP-W and HP-S diets contained an additional 24% (wt/wt) whey or isoflavone-free soy protein, respectively. Food intake, body weight, body fat, respiratory quotient (RQ), plasma cholecystokinin (CCK), glucagon like peptide-1 (GLP-1), peptide YY (PYY), and leptin were measured during and/or at the end of the study. The results showed that body fat and body weight gain were lower (P<0.05) at the end of study in rats fed HP-W or HP-S vs. control diet. The cumulative food intake measured over the 10-week study period was lower in the HP-W vs. control and HP-S groups (P<0.01). Further, HP-W fed rats exhibited lower N(2) free RQ values than did control and HP-S groups (P<0.01). Plasma concentrations of total GLP-1 were higher in HP-W and HP-S vs. control group (P<0.05), whereas plasma CCK, PYY, and leptin did not differ among the three groups. In conclusion, although dietary HP-W and HP-S each decrease body fat accumulation and body weight gain, the mechanism(s) involved appear to be different. HP-S fed rats exhibit increased fat oxidation, whereas HP-W fed rats show decreased food intake and increased fat oxidation, which may contribute to the effects of whey protein on body fat.

Study Type : Animal Study

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