Diosmin has a significant clinical effect on middle-sized vein-related trophic ulcers. - GreenMedInfo Summary
Micronized diosmin (Detralex) for vein-related trophic ulcers: European experience.
Angiol Sosud Khir. 2006;12(3):53-60. PMID: 17641615
The paper presents a meta-analysis of 5 large European studies (N - 723) on the micronized diosmin administration to patients with venous trophic ulcers (CEAP class VI). With the use of evidence-based approach, it was shown that micronized diosmin has a statistically significant clinical effect on middle-sized trophic ulcers (5 - 10 cm(2)) that persisted for 6 - 12 months. The study concludes that polyvalent venotonics are an appropriate and valuable addition to complex therapy of complicated chronic venous insufficiency..