Abstract Title:

Differential effects of natural and synthetic vitamin E on gene transcription in murine T lymphocytes.

Abstract Source:

Arch Biochem Biophys. 2010 Mar 1;495(1):49-55. Epub 2009 Dec 21. PMID: 20026030

Abstract Author(s):

Sung Nim Han, Eunice Pang, Jean-Marc Zingg, Simin Nikbin Meydani, Mohsen Meydani, Angelo Azzi

Article Affiliation:

Department of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul, South Korea.


Mice were supplemented with low and high doses of natural and synthetic vitamin E, T cells from the spleen isolated and stimulated with plate-bound anti-CD3 and soluble anti-CD28, and gene expression changes assessed by gene array experiments. The data obtained indicate significant qualitative and quantitative differences between the two vitamin forms in regulating gene expression in response to T-cell stimulation. Marker genes have been found whose expression can be considered significant in establishing the level of, and response to vitamin E for both natural and synthetic vitamin E supplementation; unique markers for synthetic vitamin E supplementation and unique markers for natural vitamin E supplementation have been identified.

Study Type : In Vitro Study
Additional Links

Print Options

Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.