Abstract Title:

Effects of vitamin E on liver DNA.

Abstract Source:

Cancer Lett. 1984 Dec;25(2):163-70. PMID: 6509435

Abstract Author(s):

P Russo, M Pala, S Parodi, C Ghiara, N Ferrari, G Vidali


Vitamin E, both in the form of dl-alpha-tocopherol and dl-alpha-tocopheryl acetate, was capable of inducing an increased alkaline elution rate of liver DNA from rats treated i.p. with the vitamin. This activity was clearly both dose- and time-dependent. A statistically significant effect was observed at dosages (1.25-5.00 mg/kg) that are in the range of biological activity of the vitamin in the rat (reabsorption-gestation bioassay). Moreover, the effect was observed at dosages that are clearly not toxic. An increased alkaline elution rate of DNA is usually interpreted as suggestive of DNA damage, however recent observations seem to indicate that functional modifications of chromatin packaging can also affect the elution rate of DNA.

Study Type : In Vitro Study

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