n/a
Article Publish Status: FREE
Abstract Title:

The effect ofpollen on the expression of, andgenes, and sperm parameters of fertile and infertile men: A controlled clinical trial.

Abstract Source:

Int J Reprod Biomed. 2021 Jun ;19(6):545-558. Epub 2021 Jul 27. PMID: 34401649

Abstract Author(s):

Soghra Fallahi, Minoo Rajaei, Mohammad Javad Hesam, Mohsen Koolivand, Kianoosh Malekzadeh

Article Affiliation:

Soghra Fallahi

Abstract:

Background: Oxidative stress is caused by the imbalance occurring between the creation and clearance of the reactive oxygen species (ROS), which is responsible for 30-40% of male infertility. The positive impact ofpollen (Date palm pollen, DPP) on the improvement of sperm parameters has been well documented in animal models.

Objective: For evaluating the effect(s) of DPP on sperm parameters, ROS levels, expression of antioxidant genes, and activity of antioxidant enzymes of infertile men.

Materials and Methods: In this controlled clinical trial, a total of 60 male case with infertility and 20 normospermic fertile men were recruited. Before and after the treatment with DPP, the case were administered 400 mg/kg of gelatinous capsules daily for 30 consecutive days and semen samples were taken. Quantitative real-time polymerase chain reaction was applied for the evaluation of the mRNA expression levels of Nuclear factor erythroid 2-related factor 2(), superoxide dismutase (), glutathione peroxidase 4(), and catalase () genes.

Results: Theexpression levels of, and(p0.05 for all) and significantly increased after treatment with DPP. The increased expressions of all antioxidant genes and enzymes significantly correlated with improvement in semen parameters including count (p = 0.01), motility (p = 0.05), and morphology (p = 0.01) of sperm. A significant correlation between the alteration ofgene expression and SOD activity,and GPX,were also observed (p = 0.05).

Conclusion: DPP can increase the expressions of, andgenes and also improve the semen quality in infertile men.

Study Type : Human Study

Print Options


Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.