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Abstract Title:

Dried Plum Ingestion Increases the Osteoblastogenic Capacity of Human Serum.

Abstract Source:

J Med Food. 2017 Jul ;20(7):653-658. Epub 2017 Apr 26. PMID: 28445075

Abstract Author(s):

Paulina Delgado Cuenca, Lama Almaiman, Simon Schenk, Mark Kern, Shirin Hooshmand

Article Affiliation:

Paulina Delgado Cuenca

Abstract:

In cell culture studies, dried plum (Prunus domestica L.) polyphenols increased osteoblast alkaline phosphatase (ALP) activity, mineralized nodule formation, and the expression of the bone marker genes runt-related transcription factor 2 (RUNX2) and osterix. The purpose of this study was to determine whether human serum collected 1 and 2 h after dried plum ingestion influenced osteoblast cell activity and gene expression. Five healthy women ingested 100 g of dried plum, and serum samples were collected at baseline (before dried plum ingestion) and 1 and 2 h postingestion of dried plum. MC3T3-E1 osteoblast cells were treated (2% of medium) with these serum samples for 3 or 9 days. Intracellular and extracellular ALP activities were significantly increased after 3 or 9 days of treatment with serum both postingestion time points, with no effect seen in baseline samples. Also, serum obtained 1 and 2 h postingestion significantly increased the mRNA expression of bone markers RUNX2 and connexin43 (CX43) after both 3 and 9 days of incubation periods. Finally, serum obtained 1 and 2 h postingestion increased the mRNA expression of β-catenin after 9 days of incubation. We conclude that osteoblast activity and functionare increased by dried plum ingestion, which may, in part, explain its beneficial effects on bone health.

Study Type : Human Study
Additional Links
Pharmacological Actions : Osteoprotective : CK(971) : AC(351)

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