Abstract Title:

Dried Plum Ingestion Increases the Osteoblastogenic Capacity of Human Serum.

Abstract Source:

J Med Food. 2017 Jul ;20(7):653-658. Epub 2017 Apr 26. PMID: 28445075

Abstract Author(s):

Paulina Delgado Cuenca, Lama Almaiman, Simon Schenk, Mark Kern, Shirin Hooshmand

Article Affiliation:

Paulina Delgado Cuenca


In cell culture studies, dried plum (Prunus domestica L.) polyphenols increased osteoblast alkaline phosphatase (ALP) activity, mineralized nodule formation, and the expression of the bone marker genes runt-related transcription factor 2 (RUNX2) and osterix. The purpose of this study was to determine whether human serum collected 1 and 2 h after dried plum ingestion influenced osteoblast cell activity and gene expression. Five healthy women ingested 100 g of dried plum, and serum samples were collected at baseline (before dried plum ingestion) and 1 and 2 h postingestion of dried plum. MC3T3-E1 osteoblast cells were treated (2% of medium) with these serum samples for 3 or 9 days. Intracellular and extracellular ALP activities were significantly increased after 3 or 9 days of treatment with serum both postingestion time points, with no effect seen in baseline samples. Also, serum obtained 1 and 2 h postingestion significantly increased the mRNA expression of bone markers RUNX2 and connexin43 (CX43) after both 3 and 9 days of incubation periods. Finally, serum obtained 1 and 2 h postingestion increased the mRNA expression of β-catenin after 9 days of incubation. We conclude that osteoblast activity and functionare increased by dried plum ingestion, which may, in part, explain its beneficial effects on bone health.

Study Type : Human Study
Additional Links
Pharmacological Actions : Osteoprotective : CK(971) : AC(351)

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