Drug-induced acute autoimmune hepatitis during combination therapy with atorvastatin and ezetimibe.
Ann Clin Biochem. 2005 Sep ;42(Pt 5):402-4. PMID: 16168199
Clinical Laboratories, University Hospital Aintree, Lower Lane, Liverpool L9 7AL, UK. [email protected]
A case is presented of a patient who developed acute hepatitis during cholesterol-lowering treatment with atorvastatin and ezetimibe. Further investigations reveal a probable drug-induced autoimmune hepatitis, and ezetimibe is considered to be the most likely causal agent. This case is the first report of an autoimmune hepatitis associated with ezetimibe therapy.