[Gut microbiome and psyche: paradigm shift in the concept of brain-gut axis].
MMW Fortschr Med. 2016 May 25 ;158 Suppl 4:12-6. Epub 2016 May 25. PMID: 27221556
Peter C Konturek
BACKGROUND: The concept of the brain-gut axis describes the communication between the central and enteric nervous system. The exchange of information takes place in both directions. The great advances in molecular medicine in recent years led to the discovery of an enormous number of microorganisms in the intestine (gut microbiome), which greatly affect the function of the brain-gut axis.
RESULTS AND CONCLUSIONS: Numerous studies indicate that the dysfunction of the brain-gut axis could lead to both inflammatory and functional diseases of the gastrointestinal tract. Moreover, it was shown that a faulty composition of the gut microbiota in childhood influences the maturation of the central nervous system and thus may favor the development of mental disorders such as autism, depression, or other. An exact causal relationship between psyche and microbiome must be clarified by further studies in order to find new therapeutic options.