Article Publish Status: FREE
Abstract Title:

E-Cigarette Flavoring Chemicals Induce Cytotoxicity in HepG2 Cells.

Abstract Source:

ACS Omega. 2021 Mar 16 ;6(10):6708-6713. Epub 2021 Mar 2. PMID: 33748584

Abstract Author(s):

Brittany P Rickard, Henry Ho, Jacqueline B Tiley, Ilona Jaspers, Kim L R Brouwer

Article Affiliation:

Brittany P Rickard


E-cigarette-related hospitalizations and deaths across the U.S. continue to increase. A high percentage of patients have elevated liver function tests indicative of systemic toxicity. This study was designed to determine the effect of e-cigarette chemicals on liver cell toxicity. HepG2 cells were exposed to flavoring chemicals (isoamyl acetate, vanillin, ethyl vanillin, ethyl maltol, l-menthol, andcinnamaldehyde), propylene glycol, and vegetable glycerin mixtures, and cell viability was measured. Data revealed that vanillin, ethyl vanillin, and ethyl maltol decreased HepG2 cell viability; repeated exposure caused increased cytotoxicity relative to single exposure, consistent with the hypothesis that frequent vaping can cause hepatotoxicity.

Study Type : In Vitro Study

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