Abstract Title:

Anticonvulsant properties of Euterpe oleracea in mice.

Abstract Source:

Neurochem Int. 2015 Nov ;90:20-7. Epub 2015 Jul 2. PMID: 26142570

Abstract Author(s):

José Rogerio Souza-Monteiro, Moisés Hamoy, Danielle Santana-Coelho, Gabriela P F Arrifano, Ricardo S O Paraense, Allan Costa-Malaquias, Jackson R Mendonça, Rafael F da Silva, Wallena S C Monteiro, Hervé Rogez, Diogo L de Oliveira, José Luiz M do Nascimento, Maria Elena Crespo-López

Article Affiliation:

José Rogerio Souza-Monteiro


Açai (Euterpe oleracea Mart.), a highly consumed fruit in Amazon, is from a common palm with remarkable antioxidant properties. Because oxidative stress and seizures are intimately linked, this study investigated the potential neuroprotective and anticonvulsant effects of commercial clarified açaijuice (EO). EO did not alter spontaneous locomotor activity. Four doses of EO were sufficient to increase latencies to both first myoclonic jerk and first generalized tonic-clonic seizure and significantly decrease the total duration of tonic-clonic seizures caused by pentylenetetrazol administration. Also, electrocortical alterations provoked by pentylenetetrazol were prevented, significantly decreasing amplitude of discharges and frequencies above 50 Hz. EO was also able to completely prevent lipid peroxidation in the cerebral cortex, showing a potent direct scavenging property. These results demonstrate for the first time that E. oleracea significantly protects against seizures and seizure-related oxidative stress, indicating an additional protection for humans who consume this fruit.

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