Article Publish Status: FREE
Abstract Title:

Early life antibiotic exposure affects pancreatic islet development and metabolic regulation.

Abstract Source:

Sci Rep. 2017 Feb 2 ;7:41778. Epub 2017 Feb 2. PMID: 28150721

Abstract Author(s):

Jiaying Li, Kaiyuan Yang, Tingting Ju, Tracy Ho, Catharine A McKay, Yanhua Gao, Shay K Forget, Stephanie R Gartner, Catherine J Field, Catherine B Chan, Benjamin P Willing

Article Affiliation:

Jiaying Li


Childhood antibiotic exposure has been recently linked with increased risk of metabolic disease later in life. A better understanding of this association would potentially provide strategies to reduce the childhood chronic disease epidemic. Therefore, we explored the underlying mechanisms using a swine model that better mimics human infants than rodents, and demonstrated that early life antibiotic exposure affects glucose metabolism 5 weeks after antibiotic withdrawal, which was associated with changes in pancreatic development. Antibiotics exerted a transient impact on postnatal gut microbiota colonization and microbial metabolite production, yet changes in the expression of key genes involved in short-chain fatty acid signaling and pancreatic development were detected in later life. These findings suggest a programming effect of early life antibiotic exposure that merits further investigation.

Study Type : Animal Study

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Sayer Ji
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