Abstract Title:

Echinacea intake induces an immune response through altered expression of leucocyte hsp70, increased white cell counts and improved erythrocyte antioxidant defences.

Abstract Source:

J Clin Pharm Ther. 2005 Aug;30(4):363-9. PMID: 15985050

Abstract Author(s):

L L Agnew, S P Guffogg, A Matthias, R P Lehmann, K M Bone, K Watson

Article Affiliation:

School of Biological, Biomedical and Molecular Sciences, University of New England, Australia.


OBJECTIVE: To study the effect of Echinacea tablets on the expression of leucocyte heat shock protein 70 (hsp70), erythrocyte haemolysis, plasma antioxidant status, serum chemistry, haematological values and plasma alkylamide concentrations.

METHOD: Eleven healthy individuals (26-61 years of age) were evaluated at baseline (day 1) and on day 15 after consuming two commercially blended Echinacea tablets daily for 14 days.

RESULTS: Echinacea supplementation enhanced the fold increase in leucocyte hsp70 expression after a mild heat shock (P=0.029). White cell counts (WCC) were also increased (P=0.043). We also observed a preventative effect against free radical induced erythrocyte haemolysis (P=0.006) indicative of an antioxidant effect.

CONCLUSION: The pilot study suggests that Echinacea may invoke an immune response through altered expression of hsp70 and increased WCC.

Study Type : Human Study

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Sayer Ji
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