Abstract Title:

Extract Enhances Natural Killer Cell Activityby Upregulating MHC II and Th1-type CD4T Cell Responses.

Abstract Source:

J Med Food. 2021 Oct ;24(10):1039-1049. PMID: 34668764

Abstract Author(s):

Soo-Jeung Park, Minhee Lee, Dakyung Kim, Dong Hwan Oh, Kodimule Shyam Prasad, Sangwon Eun, Jeongmin Lee

Article Affiliation:

Soo-Jeung Park


There are a number of factors that cause immune system disruption, including infection caused by foreign antigens and decreased immunity due to excessive exercise, and public interest in improving immunity is growing. In this study, we investigate the immunomodulatory effects of(E) extract in C57BL/6N mice that were exposed to a forced swimming exercise. There were six experimental groups as follows: wild-type, forced swimming exercise control, positive control (red ginseng, 300 mg/kg), and E (50, 100, and 200 mg/kg b.w.) groups. The mice were administered the E extract for 2 weeks. We detected chicoric acid, the active substance of E, through high-performance liquid chromatography and evaluated changes in the following laboratory values in response to forced swimmingexercise using flow cytometry and ELISA: the major histocompatibility complex (MHC), CD4and CD8T cells, Th1 and Th2 cytokines, natural killer (NK) cell activity, and number of leukocytes. Oral E intake increased levels of MHC II, CD4T cells, Th1 cytokines, and NK cell activity. In addition, E treatment increased B cell proliferation, leukocyte counts, and immunoglobulin levels. Taken together, these results suggest that the chicoric acid of E can improve immune response by controlling NK cell activity, which may be a useful function for immunomodulation systems.

Study Type : Animal Study

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