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Article Publish Status: FREE
Abstract Title:

Effect and mechanism of berberine against polycystic ovary syndrome.

Abstract Source:

Biomed Pharmacother. 2021 Mar 16 ;138:111468. Epub 2021 Mar 16. PMID: 33740526

Abstract Author(s):

Si-Wei Zhang, Jing Zhou, Hans-Jürgen Gober, Wing Ting Leung, Ling Wang

Article Affiliation:

Si-Wei Zhang

Abstract:

For women of reproductive age, polycystic ovary syndrome (PCOS) is not a rare heterogeneous endocrine disorder and metabolic dysfunction. Menstrual problems, hyperandrogenism, polycystic ovary (PCO) and infertility often affect these women, and they are also prone to metabolic syndrome (MS) and insulin resistance (IR). As an isoquinoline alkaloid, Berberine (BBR) is the main effective component of Coptis. BBR, as a multi-target, multi-path plant extract, can interfere with the development of PCOS and relate to pathological process from many aspects, with less adverse reactions. It is mentioned in this review that BBR can alleviate IR, reduce the level of serum androgen, regulate lipid metabolism and moderate chronic inflammation. BBR is often used in combination with metformin, compound cyproterone (CPA) and other drugs, in order to achieve better therapeutic effect on PCOS.

Study Type : Review

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