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Article Publish Status: FREE
Abstract Title:

Effect and Mechanisms of Quercetin for Experimental Focal Cerebral Ischemia: A Systematic Review and Meta-Analysis.

Abstract Source:

Oxid Med Cell Longev. 2022 ;2022:9749461. Epub 2022 Feb 25. PMID: 35251482

Abstract Author(s):

Chao Guo, Wen-Jun Wang, Yu-Cheng Liao, Chao Zhao, Ying Yin, Min-Na Yao, Yi Ding, Jing-Wen Wang

Article Affiliation:

Chao Guo

Abstract:

Quercetin, a naturally occurring flavonoid, is mainly extracted from tea, onions, and apples. It has the underlying neuroprotective effect on experimental ischemic stroke. A systematic review and meta-analysis were used to assess quercetin's efficacy and possible mechanisms in treating focal cerebral ischemia. Compared with the control group, twelve studies reported a remarkable function of quercetin in improving the neurological function score (NFS) (<0.05), and twelve studies reported a significant effect on reducing infarct volume (<0.05). Moreover, two and three studies showed that quercetin could alleviate blood-brain barrier (BBB) permeability and brain water content, respectively. The mechanisms of quercetin against focal cerebral ischemia are diverse, involving antioxidation, antiapoptotic, anti-inflammation, and calcium overload reduction. On the whole, the present study suggested that quercetin can exert a protective effect on experimental ischemic stroke. Although the effect size may be overestimated because of the quality of studies and possible publication bias, these results indicated that quercetin might be a promising neuroprotective agent for human ischemic stroke. This study is registered with PROSPERO, number CRD 42021275656.

Study Type : Meta Analysis, Review

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