Effect of β-caryophyllene from cloves extract on Helicobacter pylori eradication. - GreenMedInfo Summary

New antibacterial treatments againstare needed asis acquiring antibiotic resistance.β-caryophyllene is a natural bicyclic sesquiterpene, with anti-inflammatory and antimicrobial effects. This study investigates the effects of H-002119-00-001 from β-caryophyllene on the eradication ofin a mouse model, and its effects on the inflammation of the gastric mucosa. To evaluate the anti-efficacy ofβ-caryophyllene, a total of 160 mice were divided into eight groups (= 10 each) and were administered different treatments for 2 and 4 weeks.eradication was assessed using a Campylobacter-like organism (CLO) test andqPCR of the gastric mucosa. The levels of inflammation of gastric mucosa were assessed using histology and immunostaining. H-002119-00-001 decreased bacterial burden in vitro. When H-002119-00-001 was administered to mice once daily for 2 weeks, cure rates shown by the CLO test were 40.0%, 60.0%, and 70.0% in groups 6, 7, and 8, respectively.levels in gastric mucosa decreased dose-dependently after H-002119-00-001 treatment. H-002119-00-001 also reduced levels of inflammation in gastric mucosa. H-002119-00-001 improved inflammation and decreased bacterial burden in-infected mouse models. H-002119-00-001 is a promising and effective therapeutic agent for the treatment ofinfection.