Article Publish Status: FREE
Abstract Title:

Effect of Electroacupuncture on Gut Microbiota in Participants With Knee Osteoarthritis.

Abstract Source:

Front Cell Infect Microbiol. 2021 ;11:597431. Epub 2021 Oct 4. PMID: 34671567

Abstract Author(s):

Tian-Qi Wang, Ling-Ru Li, Chun-Xia Tan, Jing-Wen Yang, Guang-Xia Shi, Li-Qiong Wang, Hui Hu, Zhi-Shun Liu, Jun Wang, Tong Wang, Yong Yuan, Wen-Rui Jia, Hua Li, Xin-Wei Wang, Bin Wu, Jian-Feng Tu, Cun-Zhi Liu

Article Affiliation:

Tian-Qi Wang


A close relationship between knee osteoarthritis (KOA) and gut microbiota has recently been described. Herein, we aim to investigate the effect of electroacupuncture (EA) on gut microbiota in participants with KOA. We conducted a study of 60 participants with KOA and 30 matched healthy controls (HCs). Sixty participants were allocated to either EA group (n=30) or sham acupuncture (SA) group (n=30). Five obligatory acupoints and three adjunct acupoints were punctured in the EA group. Eight non-acupoints that were separated from conventional acupoints or meridians were used for the SA group. Participants in both groups received 24 sessions within eight weeks. Fecal microbial analyses by 16S ribosomal RNA gene sequencing were carried out after collecting stools atandweeks (Four samples with changed defecation habits were excluded). The results showed that both Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) total score (0.043) and NRS score (0.002) decreased more in EA group than those in SA group. Moreover, EA could reverse more KOA-related bacteria including,,r. The number of significantly different genera between KOA patients and HCs were less after EA treatment than that after SA treatment. This meant that EA modified the composition of the gut microbiome, making it closer to healthy people, while not significantly affecting the microbial diversity. Two genera including(=0.0163),(=0.0144) were statistically increased than baseline in EA group (paired Wilcoxon rank sum test). After EA treatment,(0.0394) was more abundant and(0.0306) was significantly reduced in patients who demonstrated adequate response than in those with inadequate response (Wilcoxon rank-sum test). Spearman correlation test between gut microbe and KOA clinical outcomes indicated thatandwas negatively correlated with NRS score, WOMAC total score, and WOMAC pain, stiffness and pain scores (<0.001 or 0.05 or 0.01), whilewas positively correlated with them (<0.05 or 0.01). Our study suggests that EA contributes to the improvement of KOA and gut microbiota could be a potential therapeutic target.

Study Type : Human Study

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