Effect of eriodictyol on collagen-induced arthritis in rats by Akt/HIF-1α pathway. - GreenMedInfo Summary

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Abstract Title:

Effect of Eriodictyol on Collagen-Induced Arthritis in Rats by Akt/HIF-1α Pathway.

Abstract Source:

Drug Des Devel Ther. 2020 ;14:1633-1639. Epub 2020 Apr 29. PMID: 32425508

Abstract Author(s):

ZhongHua Lei, Liu Ouyang, Yong Gong, ZhaoZhen Wang, Bo Yu

Article Affiliation:

ZhongHua Lei

Abstract:

Purpose: The aim of the experiment was to explore the effect of eriodictyol (ERI) on arthritis.

Methods: We established a rat model of collagen-induced rheumatoid arthritis (CIA) using type II collagen plus Freund's complete adjuvant. We evaluated the degree of paw swelling, joint pathology, inflammatory cytokine levels, and the Akt/hypoxia-inducible factor (HIF)-1α signaling pathway in the CIA rats.

Results: ERI significantly ameliorated joint swelling; improved joint pathology; and suppressed the release of interleukin-6, interleukin-1 beta, and tumor necrosis factor-alpha. Moreover, ERI inhibited the Akt/HIF-1α pathway in the joints of rats and in lipopolysaccharide-treated RAW264.7 cells.

Conclusion: ERI ameliorated arthritis in a manner involving the Akt/HIF-1α signaling pathway.

Article Published Date : Dec 31, 2019
Study Type : Animal Study
Additional Links
Substances : Eriodictyol : CK(83) : AC(55)
Diseases : Arthritis : CK(5206) : AC(1339)
Pharmacological Actions : Anti-Inflammatory Agents : CK(20859) : AC(13987), Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor : CK(316) : AC(208)

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Key Research Topics

Disease

Arthritis

Pharmacological Actions

Anti-Inflammatory Agents
Hypoxia inducible factor-1 alpha (HIF-1α) inhibitor

Substance

Eriodictyol

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