Abstract Title:

Effect of extra virgin olive oil consumption on glycemic control: A systematic review and meta-analysis.

Abstract Source:

Nutr Metab Cardiovasc Dis. 2021 Feb 24. Epub 2021 Feb 24. PMID: 33941427

Abstract Author(s):

Fereshteh Dehghani, Mojgan Morvaridzadeh, Ana B Pizarro, Tohid Rouzitalab, Masoud Khorshidi, Azimeh Izadi, Farzad Shidfar, Amirhosein Omidi, Javad Heshmati

Article Affiliation:

Fereshteh Dehghani


AIMS: Several health benefits are contributed to extra virgin olive oil (EVOO). The polyphenol fraction of EVOO may be responsible for its cardioprotective impacts. This systematic review and meta-analysis aimed to investigate the effect of EVOO intake on glycemic parameters. Electronic literature searched through 1 September 2020 across MEDLINE/PubMed, Web of Science, and SCOPUS databases to find all clinical trials that reported the effect of EVOO intake on glycemic parameters [FBS(fasting blood glucose), insulin, HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) and HbA1c (glycated hemoglobin A1c)] vs. control.

DATA SYNTHESIS: We pooled standardized mean differences (SMD) and 95% confidence intervals (CIs) from randomized clinical trials (RCTs) using random-effects models. Heterogeneity was assessed by Cochran Q-statistic and quantified (I). We found 13 related trials comprising a total of 633 subjects. In pooled analysis, EVOO intake had no effect on FBS (SMD: -0.07; 95% CI: -0.20, 0.07; I = 0.0%), insulin (SMD: -0.32; 95% CI: -0.70, 0.06; I = 38.0%), and HOMA-IR (SMD: -0.32; 95% CI: -0.75, 0.10; I = 51.0%). However, a decreasing trend was observed in these effects. Subgroup analysis based on age, health status, dose, and EVOO intake duration also did not significantly change results.

CONCLUSION: Although EVOO seems a promising hypoglycemic effects, we did not find any significant evidence that EVOO consumption impacts glucose homeostasis. Furthermore, well-designed RCTs with longer durations are still needed to evaluate the EVOO's efficacy on glycemic parameters.

Study Type : Meta Analysis, Review

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