Article Publish Status: FREE
Abstract Title:

Effect of ginkgolide B on brain metabolism and tissue oxygenation in severe haemorrhagic stroke.

Abstract Source:

Int J Clin Exp Med. 2015 ;8(3):3522-9. Epub 2015 Mar 15. PMID: 26064244

Abstract Author(s):

Chun-Ling Chi, Dong-Fang Shen, Peng-Jun Wang, Hu-Lun Li, Li Zhang

Article Affiliation:

Chun-Ling Chi


Ginkgolide B, a diterpene, is an herbal constituent isolated from the leaves of Ginkgo biloba tree. The present study demonstrates the effect of ginkgolide B in osmotherapy on brain metabolism and tissue oxygenation. Multimodality monitoring including intracranial pressure (ICP), cerebral perfusion pressure (CPP), partial pressure of brain tissue oxygen (PbtO2), lactate/pyruvate ratio (LPR) and microdialysis were employed to study the effect of ginkgolide B osmotherapy. The results demonstrated that administration of 15% solution of ginkgolide B to the comatose patients with raised ICP (>20 mm Hg) and resistant to standard therapy led to a significant decrease in ICP. The cerebral microdialysis was used to compare mean arterial blood pressure (MAP), ICP, CPP, PbtO2, brain lactate, pyruvate and glucose level after hourly intervals starting 3 h before and up to 4 h after hyperosmolar therapy. There was a decrease in ICP in 45 min from 23±14 mm Hg (P<0.001) to 18±24 mm Hg and increase in CPP after 1 h of gingkolide B infusion from 74±18 to 85±22 mm Hg (P<0.002). However there was no significant effect on MAP but PbtO2 was maintained in the range of 22-26. The peak lactate/pyruvate ratio was recorded at the time of initiation of osmotherapy (44±20) with an 18% decrease over 2 h following gingkolide B therapy. Also the brain glucose remained unaffected.

Study Type : Animal Study

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